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Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.
ADNIV; calpain 5; calpain htra-3; Calpain-5; Capn5; high-temperature requirement factor A3; HTRA3; Ncl3; nCL-3; New calpain 3; testis tissue sperm-binding protein Li 91mP; VRNI
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